Kate Beckinsale

Selene

Stephen Rea

Dr. Jacob Lane

Michael Ealy

Detective Sebastian

Theo James

David

India Eisley

Eve

Charles Dance

Thomas

Sandrine Holt

Lida

Sanny van Heteren

British newscaster

Jacob Blair

Kolb (Officer)

Robert Lawrenson

Waterfront Cop

Kurt Max Runte

Leader of the Troop

Marvin Duerkholz

Lestroy

Ron Wear

Jack Fletcher

Richard Cetrone

Lycan 1

Dan Payne

Lycan 2

Mark Gibbon

Announcing Guard

Benita Ha

Surgical Nurse

Tyler McClendon

Scientist

Panou

Old City Cop #1

Ian Rozylo

Old City Cop #2

Kristen Holden-Ried

Quint Lane

John Innes

Medical Supervisor

Lee Majdoub

Desk Guard

Catlin Adams

Olivia

Adam Greydon Reid

Med Tech

Christian Tessier

Security Guard #1

Wes Bentley

Antigen Scientist (uncredited)

Scott Speedman

Michael (archive footage) (uncredited)

Joe Censoplano

Cadillac Driver (uncredited)

Preston Cook

Antigen Surgeon (uncredited)