Wesley Snipes

Eric Brooks / Blade

Jessica Biel

Abigail Whistler

Ryan Reynolds

Hannibal King

Kris Kristofferson

Abraham Whistler

Dominic Purcell

Dracula / Drake

Parker Posey

Danica Talos

Natasha Lyonne

Sommerfield

James Remar

Ray Cumberland

John Michael Higgins

Dr. Edgar Vance

Patton Oswalt

Hedges

Callum Keith Rennie

Asher Talos

Paul Levesque

Jarko Grimwood

Françoise Yip

Virago

Mark Berry

Chief Martin Vreede

Paul Anthony

Wolfe

Michael Anthony Rawlins

Wilson Hale

Ginger Page

Zoe

Eric Bogosian

Bentley Tittle

Erica Cerra

Goth Vixen Wannabe

Clay Cullen

Stone

Shannon Powell

Woman Bystander

Birkett Turton

Dingo

Brian Steele

Drake Creature (uncredited)

Christopher Heyerdahl

Caulder