Michael Fassbender

David / Walter

Katherine Waterston

Daniels

Billy Crudup

Oram

Danny McBride

Tennessee

Demián Bichir

Lope

Carmen Ejogo

Karine

Jussie Smollett

Ricks

Callie Hernandez

Upworth

Amy Seimetz

Faris

Nathaniel Dean

Hallett

Alexander England

Ankor

Benjamin Rigby

Ledward

Uli Latukefu

Cole

Tess Haubrich

Rosenthal

Lorelei King

'Mother' (voice)

Goran D. Kleut

Xenomorph / Neomorph

Andrew Crawford

Neomorph

Tom O'Sullivan

David / Walter Double

James Franco

Jacob Branson (uncredited)

Guy Pearce

Peter Weyland (uncredited)

Noomi Rapace

Dr. Elizabeth Shaw (uncredited)